ELOVL4 antibody

Catalog No. ABIN307133

The Rabbit Polyclonal anti-ELOVL4 antibody has been validated for WB. It is suitable to detect ELOVL4 in samples from Human.

Quick Overview for ELOVL4 antibody (ABIN307133)

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELOVL4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ELOVL4 Antibody

Cross-Reactivity: Human

Characteristics: Elongation of very long chain fatty acids protein 4, ELOV4,Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptdide derived from the human ELOV4 protein

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL starting dilution). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for ELOVL4

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Alternative Name: ELOVL4

UniProt: Q9GZR5